ICR;129-Hes1<tm1Fgu> ICR;129-Hes1<tm1Fgu> C (3-6 months) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Genes Dev. 1995 9(24):3136-48.In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for profit institution for a not-for-profit research. The RECIPIENT of BIOLOGICAL resource shall obtain a prior written consent on use of it from the DEPOSITOR Dr. Ryoichiro Kageyama (E-mail: rkageyam@virus.kyoto-u.ac.jp ). (No approval form (Form D) is necessary). Itaru IMAYOSHI 条件を付加する。<br>研究成果の公表にあたって寄託者の指定する文献を引用する。Genes Dev. 1995 9(24):3136-48.<br>研究成果の公表にあたって謝辞の表明を必要とする。<br>学術機関の学術研究に限る。分与希望者は事前に 影山龍一郎 (E-mail: rkageyam@virus.kyoto-u.ac.jp) に連絡をとり、分与に関して許可を得ること。（提供承諾書（書式6）の提出は不要）。 <a href='https://brc.riken.jp/mus/pcr05979'>Genotyping protocol -PCR-</a> 影山龍一郎 RBRC05979 Hes1 KO ; Hes1 KO Hes1 KO ; Hes1 KO true Hes1遺伝子のノックアウトマウス。 Developed by Ryoichiro Kageyama, Kyoto University/IGBMC in 1994. R1 ES cells were used. The mutant mice were crossed to ICR. 今吉　格 Hes1 gene knockout mice. The first tree exons were replaced with a PGK-neo cassette. R1 [(129X1/SvJ x 129S1/Sv)F1-Kitl<+>] mouse phosphoglycerate kinase promoter (PGK promoter), Neo (E. coli), mouse Hes1 genomic DNA Ryuichiro KAGEYAMA C（3〜6か月） Necessary documents for ordering:<ol><li>Order form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx">English</A>)</li><li>Category I MTA: MTA for distribution with RIKEN BRC (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx">English</A>)</li><li>Acceptance of responsibility for living modified organism (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx">English</A>)</li></ol> 京都大学大学院医学研究科/IGBMC・影山龍一郎（1994）。R1 ES細胞由来を用いて作出。ICRと交配。 Heterozygote x Wild-type [or Crossing to Slc:ICR] Heterozygote x Wild-type [or Crossing to Slc:ICR]